Five years after a Second Civil War, a nameless Drifter runs into some trouble along the trail when she decides to go off the main road.
After being saved from some Donnor Party members, Drifter meets Ed and Emily, a brother and sister operating a make shift trading post.
Gunpowder and crew continue their search for the gunman that took out three of their tribe. Meanwhile, a mysterious stranger arrives at the trading post.
Moses tries to finish his shopping at the trading post, but runs into a little trouble. Meanwhile Gunpowder, Drain, and Cottonmouth get closer to finding out who killed their men.
Drifter attempts leave and get back on the road, but is stopped short when her actions catch up with her.
In order to protect Ed and Emily, Drifter confronts Gunpowder and his cohorts.
Weeks after leaving Ed and Emily at the trading post, Drifter runs into trouble on the Missouri/Kansas border when she crosses paths with The Regulators, a guns for hire gang lead by the sexy and violent, Mustang Sally.
While Drifter takes time to rest and heal at The Strangers camp, Sally and her boys go on a recruiting mission and run into someone along the way.
A camp meeting about Sally and The Regulators actions goes awry and all is not as it seems.
Drifter has agreed to help against her better judgement and gets an unsuspected partner as part of The Strangers plan.
While the Chief deals with the loss of his wife, a plan to save his daughter is put into motion by The Stranger with the help of a reluctant Drifter. Meanwhile, Mustang Sally lets out her frustrations.
Moon's best tracker, Eagle Eye, returns with no new information on his prey. We learn about Moons shocking past. Meanwhile, Drifter and Moses continue their trek toward Moons hideout, only to be cut short by Sally and The Regulators.
Moses has turned, Drifter is being held captive, and Moon has some questions about Agent Sands. Meanwhile Sally tries to seduce Moses, but all is not as it seems.
Drifter, Moses, and The Stranger, along with his crew, follow through on the plan and converge on the location where Jenni is being held hostage.